منابع مشابه
Prospects for gene therapy for heart failure.
Heart failure represents an enormous clinical challenge in need of effective therapeutic approaches. The possibility of gene therapy for heart failure merits consideration at this time because of improvements in vector technology; cardiac gene delivery; and, most importantly, our understanding of the molecular pathogenesis of heart failure. We will first review recent advances in cardiac gene d...
متن کاملProspects for Gene Therapy for CNS Disease
Substantial progress has been made over the last 20 years in understanding the basic biology and function of the normal nervous system, and in elucidating molecular and cellular mechanisms that underlie neurological disease. Together with these advances in understanding have come discoveries of novel genes and proteins, which collectively present an unprecedented opportunity to intervene in and...
متن کاملprospects for antifibrotic therapy
antifibrotic therapies should preferentially be targeted to the activated hepatic mesenchymal cells. those cells resemble wound healing myofibroblasts and synthesize an excess of extracellular matrix (ecm) proteins. they derive from quiescent hepatic stellate cells (hsc) and portal/perivascular (myo-) fibroblasts (mf). whereas various agents have been shown to inhibit hsc/mf proliferation and c...
متن کاملProspects for gene therapy in cardiovascular disease.
The therapeutic potential of gene therapy in cardiovascular disease such as post-angioplasty restenosis, myocardial ischaemia and severe peripheral artery disease ischemia are considered.
متن کاملGene therapy: prospects for glycolipid storage diseases.
Lysosomal storage diseases comprise a group of about 40 disorders, which in most cases are due to the deficiency of a lysosomal enzyme. Since lysosomal enzymes are involved in the degradation of various compounds, the diseases can be further subdivided according to which pathway is affected. Thus, enzyme deficiencies in the degradation pathway of glycosaminoglycans cause mucopolysaccharidosis, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1990
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod42.1.39